教师简历


系主任/教授/博士生导师

薛付忠

系主任/教授/博士生导师

  • 0531-88382140

  • 13906405997

  • xuefzh@sdu.edu.cn

  • 山东大学趵突泉校区(西校)综合楼510

薛付忠,流行病与卫生统计学专业教授,博士研究生导师。流行病与卫生统计学专业博士毕业。现任山东大学公共卫生学院副院长,山东大学公共卫生学院生物统计学系主任;兼任中华预防医学会健康保险专业委员会主任委员、中国卫生信息学会医学统计教育专业委员会副主任委员,中华预防医学会生物统计学专业委员会常务委员,中国卫生信息学会医学统计学理论与方法学专业委员会常务委员,国际生物统计学会中国分会(IBS-China)常务理事,教育部高等学校公共卫生与预防医学类专业教学指导委员会委员,《中华预防医学杂志》编委、《中国卫生统计》编委、山东省卫生人力资源协会健康管理质量控制专业委员会主任委员、山东省临床流行病学学会副主任委员、山东预防医学会学术工作委员会副主任委员、山东省医师协会健康管理与健康保险专业委员会副主任委员,山东省健康管理质量控制中心副主任委员等职。1999 年获山东大学卫生统计学专业硕士学位,2005 年获山东大学流行病与卫生统计学专业博士学位,2005年-2007年在复旦大学遗传工程国家重点实验室完成了统计遗传学与群体遗传学专业博士后研究,2009年9月-2010年10月在英国剑桥大学-MRC流行病学研究所做访问学者,2011年10月-2012年4月在美国加州大学(戴维斯)公共卫生学院做访问学者。主要研究领域包括“组学数据统计分析与系统流行病学理论方法研究与应用”、“健康/疾病风险评估与健康保险的生命历程流行病学理论方法研究与应用”、“转化医学与精准医学临床研究的设计与统计分析方法”和“空间流行病学与空间遗传学理论方法研究与应用”。先后主持和承担了国家自然科学基金面上项目9项,科技部“863”项目、 “973项目”分题子课题、国家科技支撑计划项目、国际合作项目等多项课题。以第一作者或通信作者在国内外发表论文150余篇,其中60余篇被SCI收录。获省部级奖3项,获国家发明专利1项。参编卫生部、教育部规划教材3部。   教育经历

  • 1986年毕业于山东淄博卫生医士学校;
  • 1992年毕业于山东医科大学公共卫生学院预防医学专业;
  • 1999年毕业于山东医科大学公共卫生学院卫生统计学专业,获硕士学位;
  • 2005年毕业于山东大学公共卫生学院流行病与卫生统计学专业,获博士学位;
  • 2005年5月~2007年6月复旦大学生命科学学院群体遗传学与统计遗传学专业进行博士后研究。
  工作和外出访问
  • 07~1996.07,山东省平邑县卫生防疫站,流行病学科,主任;
  • 07~2004.09,山东大学公共卫生学院,流行病与卫生统计学研究所,讲师;
  • 09~2009.05,山东大学公共卫生学院,流行病与卫生统计学研究所,副教授/硕导;
  • 06~2010.12,山东大学公共卫生学院,流行病与卫生统计学研究所,副教授/博导;
  • 01至今, 山东大学公共卫生学院,生物统计学系,教授/博导;
  • 11~2010.10,英国剑桥大学-MRC流行病学研究所,访问学者;
  • 12~2012.03,美国加州大学戴维斯分校医学院公共卫生系,访问学者;
  • 01~至今,山东大学公共卫生学院副院长/山东大学预防医学研究院副院长
  学术任职
  • 中国卫生信息学会医学统计教育专业委员会副主任委员
  • 中华预防医学会卫生统计学专业委员会常务委员
  • 中国卫生信息学会医学统计学理论与方法学专业委员会常务委员
  • 国际生物统计学会中国分会(IBS-China)常务理事
  • 教育部高等学校公共卫生与预防医学类专业教学指导委员会委员
  • 中华医学会妇女保健分会乳腺保健与乳腺疾病防治学组委员
  • 《中华预防医学杂志》和《中国卫生统计》编委
  • 山东省医学会临床流行病学学会副主任委员
  • 山东省医师协会健康管理与健康保健专业委员会副主任委员
  • 山东预防医学会常务委员、学术工作委员会副主任委员
  • 山东省健康管理质量控制中心副主任委员
  • 山东省预防医学会免疫规划分会副主任委员
  • 山东省免疫预防专家咨询委员会委员
  • 山东预防医学会慢性非传染性疾病预防与控制分会第一届委员会慢病防控技术与方法专业委员会主任委员
  • 山东预防医学会慢性非传染性疾病预防与控制分会第一届委员会副主任委员
  研究领域 组学数据统计分析与系统流行病学理论方法研究与应用、健康/疾病风险评估与生命历程流行病学理论方法研究与应用、转化医学与真实世界临床研究的设计与统计分析方法、空间流行病学与空间遗传学理论方法研究与应用。   研究项目
  1. 薛付忠 国家自然科学基金面上项目 系统流行病学中网络差异比较的统计分析方法研究(81573259),01-2019.12;(第一位)72万
  2. 薛付忠 山东省科技重大专项,基于临床组学大数据的结直肠癌精准医学技术平台构建及精准诊疗决策支持系统研发,08-2019.08 78.9万
  3. 薛付忠 山东省科技发展计划 人群冠状动脉粥样硬化早期筛查关键技术的研究(2014GSF118119) 2015.01-2017.12;(第一位)8万
  4. 薛付忠 国家自然科学基金项目,基于贝叶斯竞争风险理论的农村人群脑卒中发生和转归的适宜性风险预警策略与方法研究(81273177), 2012.10-2016.12,(第一位)60万元
  5. 薛付忠 科技部国际合作重大项目,人群脑动脉硬化性疾病早期识别关键技术合作研究(S2014ZR0461),01-2017.12,;(第一位)420万元,
  6. 薛付忠 公益性卫生行业科研专项经费项目,图像引导非小细胞肺癌个体化放疗的规范和推广应用(201402011),01-2016.12.31,承担整个项目的统计分析工作,(第一位)42万元
  7. 薛付忠 国家科技部“973”项目,气象变化对人类健康的影响与适应机制研究(2012CB9555),承担第四课题——不同区域气候敏感疾病的响应和适应机制研究(2012CB955504)中的评价性研究,01-2016.12.31,(第一位)38万元。
  8. 薛付忠 横向科研项目,健康/疾病风险评估与个性化干预系统,07-2019.7; (第一位)500万元
  9. 薛付忠 山大-山东省食品安全办公室横向合作项目,山东省食品安全评价性抽检综合评价研究,01-2017.12;(第一位)31万元
  10. 薛付忠 国家中医药管理局,中医智能化脉诊仪的开发研究--基于“系统辩证脉学”特殊脉诊技术的智能化脉诊仪开发研究,05-2019.05,(第一位)15万元
  发表论文 [1] Yuan Z, Ji J, Zhang T, Liu Y, Zhang X, Chen W, Xue F*. A novel chi-square statistic for detecting group differences between pathways in systems epidemiology. Stat Med. 2016 Sep 7. doi: 10.1002/sim.7094. [Epub ahead of print] [2] Li H, Yuan Z, Su P, Wang T, Yu Y, Sun X, Xue F*.A simulation study on matched case-control designs in the perspective of causal diagrams.BMC Med Res Methodol. 2016 Aug 20;16(1):102. doi: 10.1186/s12874-016-0206-3. [3] Zhang X, Yuan Z, Ji J, Li H, Xue F*. Network or regression-based methods for disease discrimination: a comparison study. BMC Med Res Methodol. 2016 Aug 18;16:100. doi: 10.1186/s12874-016-0207-2. [4] Zhu Q, Sun X, Ji X, Zhu L, Xu J, Wang C, Zhang C, Xue F, Liu Y.The association between gallstones and metabolic syndrome in urban Han Chinese: a longitudinal cohort study.Sci Rep. 2016 Jul 22;6:29937. doi: 10.1038/srep29937. [5] Zhang T, Zhang H, Li Y, Sun D, Li S, Fernandez C, Qi L, Harville E, Bazzano L, He J,Xue F, Chen W.Temporal Relationship Between Childhood Body Mass Index and Insulin and Its Impact on Adult Hypertension: The Bogalusa Heart Study.Hypertension. 2016 Sep;68(3):818-23. doi: 10.1161/HYPERTENSIONAHA.116.07991. Epub 2016 Jul 18. [6] Li J, Xu X, Ding G, Zhao Y, Zhao R, Xue F, Li J, Gao J, Yang J, Jiang B, Liu Q.A Cross-Sectional Study of Heat Wave-Related Knowledge, Attitude, and Practice among the Public in the Licheng District of Jinan City, China.Int J Environ Res Public Health.2016 Jun 29;13(7). pii: E648. doi: 10.3390/ijerph13070648. [7] Li R, Lin H, Liang Y, Zhang T, Luo C, Jiang Z, Xu Q, Xue F, Liu Y, Li X. The short-term association between meteorological factors and mumps in Jining, China.Sci Total Environ. 2016 Oct 15;568:1069-75. doi: 10.1016/j.scitotenv.2016.06.158. Epub 2016 Jun 25. [8]Wang S, Zhang C, Zhang G, Yuan Z, Liu Y, Ding L, Sun X, Jia H, Xue F.Association between white blood cell count and non-alcoholic fatty liver disease in urban Han Chinese: a prospective cohort study.BMJ Open. 2016 Jun 1;6(6): e010342. doi:10. 1136/bmjopen-2015-010342. [9] Li H,Yuan Z,Ji J,Xu J,Zhang T,Zhang X,Xue F*.A novel Markov Blanket-based repeated-fishing strategy for capturing phenotype-related biomarkers in big omics data.BMC Genet. 2016 Mar 9;17(1):51. doi: 10.1186/s12863-016-0358-5. [10] Zhu L, Wang X, Guo Y, Xu J, Xue F, Liu Y.Assessment of temperature effect on childhood hand, foot and mouth disease incidence (0-5years) and associated effect modifiers: A 17 cities study in Shandong Province, China, 2007-2012.Sci Total Environ. 2016 Feb 15;551-552:452-459. doi: 10.1016/j.scitotenv.2016.01.173. [11] Ji J, Yuan Z, Zhang X,Xue F*.A powerful score-based statistical test for group difference in weighted biological networks.BMC Bioinformatics. 2016 Feb 12;17(1):86.doi:10.1186/s12859-016-0916-x. [12] Xu J, Li L, Wei L, Nie Z, Yang S, Xia M, Ma T, Sun H, Zhao X, Ping Y, Zhou H, Xue F, Zhao Z, Jin L, Li S Genetic analysis of 17 Y-STR loci in Han population from Shandong Province in East China.Forensic Sci Int Genet. 2016 Jan 28. pii: S1872-4973(16)30016-3. doi: 10.1016/j.fsigen.2016.01.016. [13] Xu J, Yuan Z, Ji J, Zhang X, Li H, Wu X, Xue F, Liu Y.A powerful score-based test statistic for detecting gene-gene co-association.BMC Genet. 2016 Jan 29;17(1):31. doi: 10.1186/s12863-016-0331-3. [14] Zhang T, Du J, Yin X, Xue F, Liu Y, Li R, Luo C, Li L, Li X.Adverse Events in Treating Smear-Positive Tuberculosis Patients in China.Int J Environ Res Public Health. 2015 Dec 29;13(1). pii: E86. doi: 10.3390/ijerph13010086. [15] Gao N,Yuan Z,Tang X,Zhou X,Zhao M,Liu L,Ji J,Xue F,Ning G,Zhao J, Zhang H,Gao L.Prevalence of CHD-related metabolic comorbidity of diabetes mellitus in Northern Chinese adults: the REACTION study.J Diabetes Complications. 2015 Nov 24.pii:S1056-8727(15)00456-0.doi: 10.1016/j.jdiacomp. [16] Ding L, Zhang C, Zhang G, Zhang T, Zhao M, Ji X, Yuan Z, Liu R, Tang F, Xue F*.A new insight into the role of plasma fibrinogen in the development of metabolic syndrome from a prospective cohort study in urban Han Chinese population.Diabetol Metab Syndr. 2015 Dec 2;7:110. eCollection 2015. [17] Zhang W,Wang L,Chen Y,Tang F,Xue F,Zhang C Identification of Hypertension Predictors and Application to Hypertension Prediction in an Urban Han Chinese Population: A Longitudinal Study, 2005-2010.Prev Chronic Dis.2015 Oct 29;12:E184. doi:10.5888/pcd12. 150192 [18] Zhang Y, Zhang T, Zhang C, Tang F, Zhong N, Li H, Song X, Lin H, Liu Y, Xue F*Identification of reciprocal causality between non-alcoholic fatty liver disease and metabolic syndrome by a simplified Bayesian network in a Chinese population.BMJ Open.2015 Sep 22;5(9):e008204.doi:10.1136/bmjopen-2015-008204. [19] Song G, Xue F, Zhang C A Model Using Texture Features to Differentiate the Nature of Thyroid Nodules on Sonography.J Ultrasound Med. 2015 Aug 25. pii: 15.14.10045. [20] Tang F, Xue F,Qin P The interplay of stressful life events and coping skills on risk for suicidal behavior among youth students in contemporary China: a large scale cross-sectional study.BMC Psychiatry. 2015 Jul 31;15:182. [21] Zhu L, Yuan Z, Wang X, Li J, Wang L, Liu Y, Xue F, Liu Y The Impact of Ambient Temperature on Childhood HFMD Incidence in Inland and Coastal Area: A Two-City Study in Shandong Province, China.Int J Environ Res Public Health. 2015 Jul 23;12(8):8691-704.doi: 10.3390/ijerph120808691. [22] Yuan Z, Zhao M, Zhang B, Zhang H, Zhang X, Guan Q, Ning G, Gao L, Xue F, Zhao J Thyroid function modifies the association between ratio of triglyceride to high-density lipoprotein cholesterol and renal function: a multicenter cross-sectional study.Sci Rep.2015 Jul 16;5:11052.doi: 10.1038/srep11052. [23] Li J, Liu R, Ji X, Xue H,Zhang G, Wang C, Chen Q, Xue F, Cui L Insight into the Spectrum of Coronary Atherosclerosis in Asymptomatic Urban Han Chinese Population by Coronary Computed Tomography Angiography.PLoS One.2015 Jul 7;10(7):e0132188. doi: 10.1371/journal.pone.0132188. eCollection 2015. [24] Tian T, Yu S, Liu L, Xue F, Yuan C, Wang M, Ji C, Ma D.The Profile of T Helper Subsets in Bone Marrow Microenvironment Is Distinct for Different Stages of Acute Myeloid Leukemia Patients and Chemotherapy Partly Ameliorates These Variations.PLoS One. 2015 Jul 2;10(7):e0131761.doi:10.1371/journal. [25] Liu YX, Pang C, Liu Y, Sun XB, Li XX, Jiang SW, Xue F*. Association between Multidrug-resistant Tuberculosis and Risk Factors in China: Applying Partial Least Squares Path Modeling. PLoS One. 2015,10(5):e0128298. [26] Liu Y, Wang X, Pang C, Yuan Z, Li H, Xue F* Spatio-temporal analysis of the relationship between climate and hand, foot, and mouth disease in Shandong province, China, 2008-2012.BMC Infect Dis. 2015 Mar 24;15(1):146. doi: 10.1186/s12879-015-0901-4. [27] Zhang T, Zhang C, Zhang Y, Tang F, Li H, Zhang Q, Lin H, Wu S, Liu Y, Xue F*.Metabolic syndrome and its components as predictors of nonalcoholic fatty liver disease in a northern urban Han Chinese population: A prospective cohort study.Atherosclerosis. 2015 Mar 11;240(1):144-148. [28] Zhao M, Yang T, Chen L, Tang X, Guan Q, Zhang B, Zhang X, Zhang H, Wang C, Xu J, Hou X, Li Q, Yu C, Zhao Y, Fang L, Yuan Z, Xue F, Ning G, Gao L, Xu C, Zhao J.Subclinical Hypothyroidism Might Worsen the Effects of Aging on Serum Lipid Profiles, a Population-based Case-control Study.Thyroid. 2015 Mar 17. [29] Wang H, Du Z, Wang X, Liu Y, Yuan Z, Liu Y,Xue F*.Detecting the association between meteorological factors and hand, foot, and mouth disease using spatial panel data models.Int J Infect Dis. 2015 Mar 11. pii: S1201-9712(15)00068-5. doi: 10.1016/j.ijid.2015.03.007. [30] Zhao M, Tang X, Yang T, Zhang B, Guan Q, Shao S, Xue F, Zhang X, Liu Z, Yuan Z, Song Y, Zhang H, Fang L, Yu C, Li Q, Zhang X, Gao L, Xu C, Zhao J. Lipotoxicity,a Potential Risk Factor for The Increasing Prevalence of Subclinical Hypothyroidism? J Clin Endocrinol Metab. 2015 Mar 5:jc20143987. [31] Zhang W, Chen Q, Yuan Z, Liu J, Du Z, Tang F, Jia H, Xue F, Zhang C. A routine biomarker-based risk prediction model for metabolic syndrome in urban Han Chinese population.BMC Public Health. 2015 Jan 31;15(1):64. [32] Wang S, Liu Y, Li F, Jia H, Liu L, Xue F*. A novel quantitative body shape score for detecting association between obesity and hypertension in China. BMC Public Health.2015 Jan 17;15(1):7. [33] Ji J, Yuan Z, Zhang X, Li F, Xu J, Liu Y, Li H, Wang J, Xue F*. Detection for pathway effect contributing to disease in systems epidemiology with a case-control design.BMJ Open. 2015 Jan 16;5(1):e006721. doi: 10.1136/bmjopen-2014-00672 [34] Liu J, Lin H, Zhang C, Wang L, Wu S, Zhang D, Tang F, Xue F, Liu Y. Non-alcoholic fatty liver disease associated with gallstones in females rather than males:a longitudinal cohort study in Chinese urban population.BMC Gastroenterol.2014 Dec 13;14(1):213. [35] Wang SK, Ma W, Wang S, Yi XR, Jia HY, Xue F*. Obesity and Its Relationship with Hypertension among Adults 50 Years and Older in Jinan, China. PLoS One.2014 Dec 17;9 (12):e114424. [36] Zhang X, Xue F, Liu H, Zhu D, Peng B, Wiemels JL, Yang X. Integrative Bayesian variable selection with gene-based informative priors for genome-wide association studies.BMC Genet.2014 Dec 10;15(1):130. [37] Yuan Z,Zhang X, Li F, Zhao J,Xue F*.Comparing partial least square approaches in a gene-or region-based association study for multiple quantitative phenotypes.Hum Biol.2014 Feb;86(1):51-8 [38] Zhao M, Liu F, Liu W, Ji X, Xue F* Health management in China. Int J Cardiol. 2014.176(1): 234. [39] Du Z,Wang Z,Liu Y,Wang H,Xue F,Liu Y.Ecological niche modeling for predicting the potential risk areas of severe fever with thrombocytopenia syndrome. Int J Infect Dis.2014.26C:1-8. [40] Zhang T,Zhang Y,Zhang C,Tang F, Li H,Zhang Q, Lin H, Wu S, Liu Y,Xue F*Prediction of metabolic syndrome by non-alcoholic fatty liver disease in northern urban Han Chinese population: a prospective cohort study.PLoS One.2014. 9(5):e96651. [41] Wu S,Lin H, Zhang C,Zhang Q,Zhang D,Zhang Y,Meng W,Zhu Z,Tang F,Xue F,Liu Y.Association between erythrocyte parameters and metabolic syndrome in urban Han Chinese: a longitudinal cohort study.BMC Public Health.2013.13:989. [42] Zhu Z, Liu Y, Zhang C,Yuan Z,Zhang Q,Tang F,Lin H,Zhang Y,Liu L,Xue F*.Identification of cardiovascular risk components in urban Chinese with metabolic syndrome and application to coronary heart disease prediction: a longitudinal study. PLoS One.2013 Dec 17;8(12):e84204. [43] Li F,Zhao J,Yuan Z,Zhang X,Ji J,Xue F*.A powerful latent variable method for detecting and characterizing gene-based gene-gene interaction on multiple quantitative traits.BMC Genet.2013 Sep 23;14:89. [44] Yuan Z,Liu H,Zhang X,Li F,Zhao J,Zhang F,Xue F*. From interaction to co-association--a Fisher r-to-z transformation-based simple statistic for real world genome-wide association study.PLoS One.2013 Jul 29;8(7):e70774. [45] Liu L,Xue F,Ma J,Ma M,Long Y,Newschaffer CJ.Social position and chronic conditions across the life span and risk of stroke: a life course epidemiological analysis of22847 American adults in ages over 50.Int J Stroke.2013 Oct;8 Suppl A100:50-5. [46] Zhang X,Yang X,Yuan Z,Liu Y,Li F,Peng B,Zhu D,Zhao J,Xue F*.A PLSPM-Based Test Statistic for Detecting Gene-Gene Co-Association in Genome-Wide Association Study with Case-Control Design.PLoS One.2013 Apr 19;8(4):e62129. [47] Yuan Z, Gao Q, He Y,Zhang X,Li F,Zhao J,Xue F*.Detection for gene-gene co-association via kernel canonical correlation analysis.BMC Genet.2012 Oct 8;13(1):83. [48] Xue F*, Li S, Luan J, Yuan Z, Luben RN, Khaw KT, Wareham NJ, Loos RJ, Zhao JH*. A latent variable partial least squares path modeling approach to regional association and polygenic effect with applications to a human obesity study. PLoS One.2012;7(2):e31927 [49] Li M,Heng X,Tao R,Liu J,Zhang L,Sun X,Wang L,Wu Q,Che F*,Xue F* .A genetic epidemiological survey of idiopathic epilepsy in the Chinese Han population.Epilepsy Res.2012;98(2-3):199-205. [50] Zhang Q, Zhang C, Song X, Lin H, Zhang D, Meng W, Zhang Y,Zhu Z, Tang F, Liu L,Yang X, Xue F*. A longitudinal cohort based association study between uric acid leveland metabolic syndrome in Chinese Han urban male population. BMC Public Health.2012 Jun 8;12:419. [51] Li X,Sun X,Jin L,Xue F*. Worldwide spatial genetic structure of angiotensin-converting enzyme gene: a new evolutionary ecological evidence for the thrifty genotypehypothesis.Eur J Hum Genet.2011;19(9):1002-1008. [52] Gao Q,He Y,Yuan Z,Zhao J,Zhang B, Xue F*.Gene-or region-based association study via kernel principal component analysis.BMC Genet.2011 Aug 26;12:75. [53] Peng Q,Zhao J,Xue F*.A gene-based method for detecting gene-gene co-association in a case-control association study.Eur J Hum Genet.2010;18(5):582-587. [54] Peng Q,Zhao J*,Xue F*.PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs.BMC Genet. 2010 Jan 26;11:6. [55] Zheng Q, Shi Y, Yang Z, Xu X, Wang L, Xue F, Gu HF, Chen ZJ*. Family-based association study of the MCF2L2 gene and polycystic ovary syndrome. Gynecol ObstetInvest.2009;68(3):171-173. [56] Xue F*,Wang Y,Xu S,Zhang F,Wen B,Wu X,Lu M,Deka R,Qian J,Jin L*.A spatial analysis of genetic structure of human populations in China reveals distinct difference betweenmaternal and paternal lineages.Eur J Hum Genet.2008;16(6):705-717. [57] Zhao P,Ma DX,Yu S,Xue FZ,Zhu WW,Shao N,Zhang JR,Ji CY.The development of Chinese specific human cytomegalovirus polyepitope recombinant vaccine.Antiviral Res.2012 Feb; 93(2):260-9. [58] Liu Y, Jiang S, Liu Y, Wang R, Li X, Yuan Z, Wang L, Xue F*. Spatial epidemiology and spatial ecology study of worldwide drug-resistant tuberculosis. Int J HealthGeogr. 2011Aug3;10:50. [59] Sun L, Shao Q, Wang ZQ, Kang DM, Li SW, Li XG, Xue FZ, Wang JZ. Spatial structure of rodent populations and infection patterns of hantavirus in seven villages of ShandongProvince from February 2006 to January 2007.Chin Med J (Engl).2011 Jun;124(11):1639-46. [60] Xue F*, Wang J, Hu P,Ma D,Liu J,Li G,Zhang L,Wu M,Sun G,Hou H. Identification of spatial genetic boundaries using a multifractal model in human population genetics.HumBiol.2005;77(5):577-617 [61] Xue F*,Wang J,Ma D,Li G,Hu P.Spatial genetic structure of two HIV-I-resistant polymorphisms (CCR2-64 I and SDF1-3'A) alleles in population of Shandong Province,China.BiomedEnviron Sci. Aug 2005(18):241-253 [62] Xue F*, Wang J,Hu P,Li G.The “Kriging” model of spatial genetic structure in human population genetics.Yi Chuan Xue Bao.Mar 2005(32):219-233 [63] Xue F*, Wang J,Hu P,Guo Y,Li G.Forecasting system on spatial coverage of cumulative phenotypic frequency of HLA class I for designing HLA-based vaccines in China.免疫学杂志.2005(21):136-141 [64] 高青松,薛付忠*. 非线性主成分分析中数据非线性特征的检验方法. 中国卫生统计,2011, 28(6):34-39. [65] 齐方,蓉蓉,薛付忠*.贝叶斯网络模型在中药整体药性特征分析中的应用. 山东大学学报(医学版),2011, 第5期:147-152. [66] 高青松,薛付忠*. 核主成分logistic回归模型在非线性关联分析中的应用. 山东大学学报(医学版),2011,第5期:140-142. [67] 李骁,薛付忠*.地理权重回归在人类群体空间遗传结构中的应用. 山东大学学报(医学版),2011,第2期:119-124. [68] 刘云霞,刘言训,薛付忠*.结核病的生态学研究进展. 中国防痨杂志, 2011,第1期:66-70. [69] 李明,车峰远,薛付忠*.癫痫危险因素病例对照研究. 中国公共卫生, 2010, 第6期:789-790. [70] 尹方方,薛付忠*,胡平.沂蒙山区老年人长寿影响因素病例对照研究. 中国公共卫生, 2010,第4期: 405-406. [71] 彭倩倩,薛付忠*. Permutation-PCA方法在病例对照关联分析中不同遗传模型下的表现. 山东大学自然科学学报(医学版)2009,,03(47):94-97. [72] 张茜,薛付忠*.类群体遗传空间结构分析的典型趋势面模型. 山东大学自然科学学报(医学版),2009;第2期. [73] 高杰,薛付忠*. Ripley's L指数与最近邻空间热点分析在流行病学标点地图分析中的应用. 山东大学自然科学学报(医学版),2009,04(47):90-93 .   出版教材/专著
  • 2014年7月,公共卫生硕士(MPH)系列教材《医学数据分析》,复旦大学出版社,编委
  • 2010年8月, 全国高等学校教材8年制及7年制教材《医学统计学》第二版 ,人民卫生出版社,编委
  • 2008年12月,全国高等学校医学规划教材《医学统计学》第二版,高等教育出版社,编委
  • 2008年12月,全国高等学校医学规划教材《医学统计学实习指导》第二版,高等教育出版社,编委
  • 2008年3月,全国高等医学院校研究生规划教材《统计分析在医学课题中的应用》,人民卫生出版社,编委
  • 2005年8月,流行病学研究方法与应用(第二版),科学出版社,编委
  已获奖项
  • 山东省自然科学创新奖(人才类)一等奖, 2014
  • 中药寒热药性科学内涵及其表征体系的研究与应用,山东省科技进步一等奖,2013(第六位)
  • 多表位疫苗设计的理论免疫应答率预测系统及其控制方法,国家发明专利,2010;(第一位)
  • 空间流行病学技术方法研究及其在肾综合征出血热防控中的应用,山东省科技进步三等奖,2009(第一位)
  • 人类群体空间遗传结构的异质性理论与定量分析方法,优秀博士论文,2005
  • 疾病的时空数学模型的相关研究及其应用,优秀硕士论文,2000
  参加的学术活动
  • 中国卫生统计学会2011年会,7.23-25,第四军医大学,西安
  • 第二届国际生物统计研讨会,7.5-7,中国人民大学,北京
  • 中国卫生统计学会2012年会,7.23-26,中南大学,长沙
  • 中国卫生统计学会2013年会,8.18-21,山东大学,济南
  • 中美肿瘤流行病学和生物统计学研讨会, 2014.5 华中科技大学  武汉
  • 统计遗传学国际研讨会 6.23-6.25,    太原
  • 第三届国际生物统计研讨会,2014,6.27-28,四川大学,成都
  • 中国卫生统计学会2014年会,7.20-7.22,南方医科大学,广州
  • 中国卫生信息学会30周年学术研讨会 12   南宁
  • 中国生物医学大数据统计方法学组首届研讨会 12,16-18 重庆
  • 2015统计遗传与基因组学研讨会 7 山西医科大学 太原
  • 中国卫生统计学会2015年会,7.28-8.1, 山西医科大学 太原

教育经历
  • 1986年毕业于山东淄博卫生医士学校;
  • 1992年毕业于山东医科大学公共卫生学院预防医学专业;
  • 1999年毕业于山东医科大学公共卫生学院卫生统计学专业,获硕士学位;
  • 2005年毕业于山东大学公共卫生学院流行病与卫生统计学专业,获博士学位;
  • 2005年5月~2007年6月复旦大学生命科学学院群体遗传学与统计遗传学专业进行博士后研究。
  • 工作和外出访问
  • 1986.07~1996.07,山东省平邑县卫生防疫站,流行病学科,主任;
  • 1999.07~2004.09,山东大学公共卫生学院,流行病与卫生统计学研究所,讲师;
  • 2004.09~2009.05,山东大学公共卫生学院,流行病与卫生统计学研究所,副教授/硕导;
  • 2009.06~2010.12,山东大学公共卫生学院,流行病与卫生统计学研究所,副教授/博导;
  • 2011.01至今, 山东大学公共卫生学院,生物统计学系,教授/博导;
  • 2009.11~2010.10,英国剑桥大学-MRC流行病学研究所,访问学者;
  • 2011.12~2012.03,美国加州大学戴维斯分校医学院公共卫生系,访问学者;
  • 2008.01~至今,山东大学公共卫生学院副院长/山东大学预防医学研究院副院长
  • 学术任职
  • 中国卫生信息学会医学统计教育专业委员会副主任委员
  • 中华预防医学会卫生统计学专业委员会常务委员
  • 中国卫生信息学会医学统计学理论与方法学专业委员会常务委员
  • 国际生物统计学会中国分会(IBS-China)常务理事
  • 教育部高等学校公共卫生与预防医学类专业教学指导委员会委员
  • 中华医学会妇女保健分会乳腺保健与乳腺疾病防治学组委员
  • 《中华预防医学杂志》和《中国卫生统计》编委
  • 山东省医学会临床流行病学学会副主任委员
  • 山东省医师协会健康管理与健康保健专业委员会副主任委员
  • 山东预防医学会常务委员、学术工作委员会副主任委员
  • 山东省健康管理质量控制中心副主任委员
  • 山东省预防医学会免疫规划分会副主任委员
  • 山东省免疫预防专家咨询委员会委员
  • 山东预防医学会慢性非传染性疾病预防与控制分会第一届委员会慢病防控技术与方法专业委员会主任委员
  • 山东预防医学会慢性非传染性疾病预防与控制分会第一届委员会副主任委员
  • 研究领域
  • 组学数据统计分析与系统流行病学理论方法研究与应用、健康/疾病风险评估与生命历程流行病学理论方法研究与应用、转化医学与真实世界临床研究的设计与统计分析方法、空间流行病学与空间遗传学理论方法研究与应用。
  • 研究项目
  • 薛付忠 国家自然科学基金面上项目 系统流行病学中网络差异比较的统计分析方法研究(81573259),2016.01-2019.12;(第一位)72万
  • 薛付忠 山东省科技重大专项,基于临床组学大数据的结直肠癌精准医学技术平台构建及精准诊疗决策支持系统研发,2015.08-2019.08 78.9万
  • 薛付忠 山东省科技发展计划 人群冠状动脉粥样硬化早期筛查关键技术的研究(2014GSF118119) 2015.01-2017.12;(第一位)8万
  • 薛付忠 国家自然科学基金项目,基于贝叶斯竞争风险理论的农村人群脑卒中发生和转归的适宜性风险预警策略与方法研究(81273177), 2012.10-2016.12,(第一位)60万元
  • 薛付忠 科技部国际合作重大项目,人群脑动脉硬化性疾病早期识别关键技术合作研究(S2014ZR0461),2015.01-2017.12,;(第一位)420万元,
  • 薛付忠 公益性卫生行业科研专项经费项目,图像引导非小细胞肺癌个体化放疗的规范和推广应用(201402011),2014.01-2016.12.31,承担整个项目的统计分析工作,(第一位)42万元
  • 薛付忠 国家科技部“973”项目,气象变化对人类健康的影响与适应机制研究(2012CB9555),承担第四课题——不同区域气候敏感疾病的响应和适应机制研究(2012CB955504)中的评价性研究,2014.01-2016.12.31,(第一位)38万元。
  • 薛付忠 横向科研项目,健康/疾病风险评估与个性化干预系统,2014.07-2019.7; (第一位)500万元
  • 薛付忠 山大-山东省食品安全办公室横向合作项目,山东省食品安全评价性抽检综合评价研究,2014.01-2017.12;(第一位)31万元
  • 薛付忠 国家中医药管理局,中医智能化脉诊仪的开发研究--基于“系统辩证脉学”特殊脉诊技术的智能化脉诊仪开发研究,2015.05-2019.05,(第一位)15万元
  • 发表论文

    [1] Yuan Z, Ji J, Zhang T, Liu Y, Zhang X, Chen W, Xue F*. A novel chi-square statistic for detecting group differences between pathways in systems epidemiology. Stat Med. 2016 Sep 7. doi: 10.1002/sim.7094. [Epub ahead of print]
    [2] Li H, Yuan Z, Su P, Wang T, Yu Y, Sun X, Xue F*.A simulation study on matched case-control designs in the perspective of causal diagrams.BMC Med Res Methodol. 2016 Aug 20;16(1):102. doi: 10.1186/s12874-016-0206-3.
    [3] Zhang X, Yuan Z, Ji J, Li H, Xue F*. Network or regression-based methods for disease discrimination: a comparison study. BMC Med Res Methodol. 2016 Aug 18;16:100. doi: 10.1186/s12874-016-0207-2.
    [4] Zhu Q, Sun X, Ji X, Zhu L, Xu J, Wang C, Zhang C, Xue F, Liu Y.The association between gallstones and metabolic syndrome in urban Han Chinese: a longitudinal cohort study.Sci Rep. 2016 Jul 22;6:29937. doi: 10.1038/srep29937.
    [5] Zhang T, Zhang H, Li Y, Sun D, Li S, Fernandez C, Qi L, Harville E, Bazzano L, He J,Xue F, Chen W.Temporal Relationship Between Childhood Body Mass Index and Insulin and Its Impact on Adult Hypertension: The Bogalusa Heart Study.Hypertension. 2016 Sep;68(3):818-23. doi: 10.1161/HYPERTENSIONAHA.116.07991. Epub 2016 Jul 18.
    [6] Li J, Xu X, Ding G, Zhao Y, Zhao R, Xue F, Li J, Gao J, Yang J, Jiang B, Liu Q.A Cross-Sectional Study of Heat Wave-Related Knowledge, Attitude, and Practice among the Public in the Licheng District of Jinan City, China.Int J Environ Res Public Health.2016 Jun 29;13(7). pii: E648. doi: 10.3390/ijerph13070648.
    [7] Li R, Lin H, Liang Y, Zhang T, Luo C, Jiang Z, Xu Q, Xue F, Liu Y, Li X. The short-term association between meteorological factors and mumps in Jining, China.Sci Total Environ. 2016 Oct 15;568:1069-75. doi: 10.1016/j.scitotenv.2016.06.158. Epub 2016 Jun 25.
    [8]Wang S, Zhang C, Zhang G, Yuan Z, Liu Y, Ding L, Sun X, Jia H, Xue F.Association between white blood cell count and non-alcoholic fatty liver disease in urban Han Chinese: a prospective cohort study.BMJ Open. 2016 Jun 1;6(6): e010342. doi:10. 1136/bmjopen-2015-010342.
    [9] Li H,Yuan Z,Ji J,Xu J,Zhang T,Zhang X,Xue F*.A novel Markov Blanket-based repeated-fishing strategy for capturing phenotype-related biomarkers in big omics data.BMC Genet. 2016 Mar 9;17(1):51. doi: 10.1186/s12863-016-0358-5.
    [10] Zhu L, Wang X, Guo Y, Xu J, Xue F, Liu Y.Assessment of temperature effect on childhood hand, foot and mouth disease incidence (0-5years) and associated effect modifiers: A 17 cities study in Shandong Province, China, 2007-2012.Sci Total Environ. 2016 Feb 15;551-552:452-459. doi: 10.1016/j.scitotenv.2016.01.173.
    [11] Ji J, Yuan Z, Zhang X,Xue F*.A powerful score-based statistical test for group difference in weighted biological networks.BMC Bioinformatics. 2016 Feb 12;17(1):86.doi:10.1186/s12859-016-0916-x.
    [12] Xu J, Li L, Wei L, Nie Z, Yang S, Xia M, Ma T, Sun H, Zhao X, Ping Y, Zhou H, Xue F, Zhao Z, Jin L, Li S Genetic analysis of 17 Y-STR loci in Han population from Shandong Province in East China.Forensic Sci Int Genet. 2016 Jan 28. pii: S1872-4973(16)30016-3. doi: 10.1016/j.fsigen.2016.01.016.
    [13] Xu J, Yuan Z, Ji J, Zhang X, Li H, Wu X, Xue F, Liu Y.A powerful score-based test statistic for detecting gene-gene co-association.BMC Genet. 2016 Jan 29;17(1):31. doi: 10.1186/s12863-016-0331-3.
    [14] Zhang T, Du J, Yin X, Xue F, Liu Y, Li R, Luo C, Li L, Li X.Adverse Events in Treating Smear-Positive Tuberculosis Patients in China.Int J Environ Res Public Health. 2015 Dec 29;13(1). pii: E86. doi: 10.3390/ijerph13010086.
    [15] Gao N,Yuan Z,Tang X,Zhou X,Zhao M,Liu L,Ji J,Xue F,Ning G,Zhao J, Zhang H,Gao L.Prevalence of CHD-related metabolic comorbidity of diabetes mellitus in Northern Chinese adults: the REACTION study.J Diabetes Complications. 2015 Nov 24.pii:S1056-8727(15)00456-0.doi: 10.1016/j.jdiacomp.
    [16] Ding L, Zhang C, Zhang G, Zhang T, Zhao M, Ji X, Yuan Z, Liu R, Tang F, Xue F*.A new insight into the role of plasma fibrinogen in the development of metabolic syndrome from a prospective cohort study in urban Han Chinese population.Diabetol Metab Syndr. 2015 Dec 2;7:110. eCollection 2015.
    [17] Zhang W,Wang L,Chen Y,Tang F,Xue F,Zhang C Identification of Hypertension Predictors and Application to Hypertension Prediction in an Urban Han Chinese Population: A Longitudinal Study, 2005-2010.Prev Chronic Dis.2015 Oct 29;12:E184. doi:10.5888/pcd12. 150192
    [18] Zhang Y, Zhang T, Zhang C, Tang F, Zhong N, Li H, Song X, Lin H, Liu Y, Xue F*Identification of reciprocal causality between non-alcoholic fatty liver disease and metabolic syndrome by a simplified Bayesian network in a Chinese population.BMJ Open.2015 Sep 22;5(9):e008204.doi:10.1136/bmjopen-2015-008204.
    [19] Song G, Xue F, Zhang C A Model Using Texture Features to Differentiate the Nature of Thyroid Nodules on Sonography.J Ultrasound Med. 2015 Aug 25. pii: 15.14.10045.
    [20] Tang F, Xue F,Qin P The interplay of stressful life events and coping skills on risk for suicidal behavior among youth students in contemporary China: a large scale cross-sectional study.BMC Psychiatry. 2015 Jul 31;15:182.
    [21] Zhu L, Yuan Z, Wang X, Li J, Wang L, Liu Y, Xue F, Liu Y The Impact of Ambient Temperature on Childhood HFMD Incidence in Inland and Coastal Area: A Two-City Study in Shandong Province, China.Int J Environ Res Public Health. 2015 Jul 23;12(8):8691-704.doi: 10.3390/ijerph120808691.
    [22] Yuan Z, Zhao M, Zhang B, Zhang H, Zhang X, Guan Q, Ning G, Gao L, Xue F, Zhao J Thyroid function modifies the association between ratio of triglyceride to high-density lipoprotein cholesterol and renal function: a multicenter cross-sectional study.Sci Rep.2015 Jul 16;5:11052.doi: 10.1038/srep11052.
    [23] Li J, Liu R, Ji X, Xue H,Zhang G, Wang C, Chen Q, Xue F, Cui L Insight into the Spectrum of Coronary Atherosclerosis in Asymptomatic Urban Han Chinese Population by Coronary Computed Tomography Angiography.PLoS One.2015 Jul 7;10(7):e0132188. doi: 10.1371/journal.pone.0132188. eCollection 2015.
    [24] Tian T, Yu S, Liu L, Xue F, Yuan C, Wang M, Ji C, Ma D.The Profile of T Helper Subsets in Bone Marrow Microenvironment Is Distinct for Different Stages of Acute Myeloid Leukemia Patients and Chemotherapy Partly Ameliorates These Variations.PLoS One. 2015 Jul 2;10(7):e0131761.doi:10.1371/journal.
    [25] Liu YX, Pang C, Liu Y, Sun XB, Li XX, Jiang SW, Xue F*. Association between Multidrug-resistant Tuberculosis and Risk Factors in China: Applying Partial Least Squares Path Modeling. PLoS One. 2015,10(5):e0128298.
    [26] Liu Y, Wang X, Pang C, Yuan Z, Li H, Xue F* Spatio-temporal analysis of the relationship between climate and hand, foot, and mouth disease in Shandong province, China, 2008-2012.BMC Infect Dis. 2015 Mar 24;15(1):146. doi: 10.1186/s12879-015-0901-4.
    [27] Zhang T, Zhang C, Zhang Y, Tang F, Li H, Zhang Q, Lin H, Wu S, Liu Y, Xue F*.Metabolic syndrome and its components as predictors of nonalcoholic fatty liver disease in a northern urban Han Chinese population: A prospective cohort study.Atherosclerosis. 2015 Mar 11;240(1):144-148.
    [28] Zhao M, Yang T, Chen L, Tang X, Guan Q, Zhang B, Zhang X, Zhang H, Wang C, Xu J, Hou X, Li Q, Yu C, Zhao Y, Fang L, Yuan Z, Xue F, Ning G, Gao L, Xu C, Zhao J.Subclinical Hypothyroidism Might Worsen the Effects of Aging on Serum Lipid Profiles, a Population-based Case-control Study.Thyroid. 2015 Mar 17.
    [29] Wang H, Du Z, Wang X, Liu Y, Yuan Z, Liu Y,Xue F*.Detecting the association between meteorological factors and hand, foot, and mouth disease using spatial panel data models.Int J Infect Dis. 2015 Mar 11. pii: S1201-9712(15)00068-5. doi: 10.1016/j.ijid.2015.03.007.
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    出版教材/专著
  • 2014年7月,公共卫生硕士(MPH)系列教材《医学数据分析》,复旦大学出版社,编委
  • 2010年8月, 全国高等学校教材8年制及7年制教材《医学统计学》第二版 ,人民卫生出版社,编委
  • 2008年12月,全国高等学校医学规划教材《医学统计学》第二版,高等教育出版社,编委
  • 2008年12月,全国高等学校医学规划教材《医学统计学实习指导》第二版,高等教育出版社,编委
  • 2008年3月,全国高等医学院校研究生规划教材《统计分析在医学课题中的应用》,人民卫生出版社,编委
  • 2005年8月,流行病学研究方法与应用(第二版),科学出版社,编委
  • 已获奖项
  • 山东省自然科学创新奖(人才类)一等奖, 2014
  • 中药寒热药性科学内涵及其表征体系的研究与应用,山东省科技进步一等奖,2013(第六位)
  • 多表位疫苗设计的理论免疫应答率预测系统及其控制方法,国家发明专利,2010;(第一位)
  • 空间流行病学技术方法研究及其在肾综合征出血热防控中的应用,山东省科技进步三等奖,2009(第一位)
  • 人类群体空间遗传结构的异质性理论与定量分析方法,优秀博士论文,2005
  • 疾病的时空数学模型的相关研究及其应用,优秀硕士论文,2000
  • 参加的学术活动
  • 中国卫生统计学会2011年会,2011.7.23-25,第四军医大学,西安
  • 第二届国际生物统计研讨会,2012.7.5-7,中国人民大学,北京
  • 中国卫生统计学会2012年会,2012.7.23-26,中南大学,长沙
  • 中国卫生统计学会2013年会,2013.8.18-21,山东大学,济南
  • 中美肿瘤流行病学和生物统计学研讨会, 2014.5 华中科技大学 武汉
  • 统计遗传学国际研讨会 2014.6.23-6.25, 太原
  • 第三届国际生物统计研讨会,2014,6.27-28,四川大学,成都
  • 中国卫生统计学会2014年会,2014.7.20-7.22,南方医科大学,广州
  • 中国卫生信息学会30周年学术研讨会 2014.12 南宁
  • 中国生物医学大数据统计方法学组首届研讨会 12,16-18 重庆
  • 2015统计遗传与基因组学研讨会 15.7 山西医科大学 太原
  • 中国卫生统计学会2015年会,2015.7.28-8.1, 山西医科大学 太原